Exploring the Molecular Conformation Space by Soft Molecule-Surface Collision.

ABSTRACT: Biomolecules function by adopting multiple conformations. Such dynamics are governed by the conformation landscape whose study requires characterization of the ground and excited conformation states. Here, the conformational landscape of a molecule is sampled by exciting an initial gas-phase molecular conformer into diverse conformation states, using soft molecule-surface collision (0.5-5.0 eV). The resulting ground and excited molecular conformations, adsorbed on the surface, are imaged at the single-molecule level. This technique permits the exploration of oligosaccharide conformations, until now, limited by the high flexibility of oligosaccharides and ensemble-averaged analytical methods. As a model for cellulose, cellohexaose chains are observed in two conformational extremes, the typi

SUBMITTER: Anggara K 

PROVIDER: S-EPMC7760097 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature