Ontology highlight
ABSTRACT:
SUBMITTER: Idilli AI
PROVIDER: S-EPMC7760354 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Idilli Aurora Irene AI Pazzi Cecilia C Dal Pozzolo Francesca F Roccuzzo Michela M Mione Maria Caterina MC
Genes 20201130 12
Cohesin is a protein complex consisting of four core subunits responsible for sister chromatid cohesion in mitosis and meiosis, and for 3D genome organization and gene expression through the establishment of long distance interactions regulating transcriptional activity in the interphase. Both roles are important for telomere integrity, but the role of cohesin in telomere maintenance mechanisms in highly replicating cancer cells in vivo is poorly studied. Here we used a zebrafish model of brain ...[more]