Ontology highlight
ABSTRACT:
SUBMITTER: Brasic JR
PROVIDER: S-EPMC7760509 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Brašić James R JR Nandi Ayon A Russell David S DS Jennings Danna D Barret Olivier O Mathur Anil A Slifer Keith K Sedlak Thomas T Martin Samuel D SD Brinson Zabecca Z Vyas Pankhuri P Seibyl John P JP Berry-Kravis Elizabeth M EM Wong Dean F DF Budimirovic Dejan B DB
Brain sciences 20201124 12
Glutamatergic receptor expression is mostly unknown in adults with fragile X syndrome (FXS). Favorable behavioral effects of negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGluR<sub>5</sub>) in <i>fmr1</i> knockout (KO) mouse models have not been confirmed in humans with FXS. Measurement of cerebral mGluR<sub>5</sub> expression in humans with FXS exposed to NAMs might help in that effort. We used positron emission tomography (PET) to measure the mGluR<sub ...[more]