Ontology highlight
ABSTRACT:
SUBMITTER: Gallardo F
PROVIDER: S-EPMC7760631 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Biomedicines 20201126 12
As a live biologic agent, oncolytic vaccinia virus has the ability to target and selectively amplify at tumor sites. We have previously reported that deletion of thymidine kinase and ribonucleotide reductase genes in vaccinia virus can increase the safety and efficacy of the virus. Here, to allow direct visualization of the viral genome in living cells, we incorporated the ANCH target sequence and the OR3-Santaka gene in the double-deleted vaccinia virus. Infection of human tumor cells with ANCH ...[more]