Ontology highlight
ABSTRACT:
SUBMITTER: Robles-Vera I
PROVIDER: S-EPMC7761232 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Robles-Vera Iñaki I de la Visitación Néstor N Sánchez Manuel M Gómez-Guzmán Manuel M Jiménez Rosario R Moleón Javier J González-Correa Cristina C Romero Miguel M Yang Tao T Raizada Mohan K MK Toral Marta M Duarte Juan J
Antioxidants (Basel, Switzerland) 20201128 12
Microbiota is involved in the host blood pressure (BP) regulation. The immunosuppressive drug mofetil mycophenolate (MMF) ameliorates hypertension. The present study analyzed whether MMF improves dysbiosis in mineralocorticoid-induced hypertension. Male Wistar rats were assigned to three groups: untreated (CTR), deoxycorticosterone acetate (DOCA)-salt, and DOCA treated with MMF for 4 weeks. MMF treatment reduced systolic BP, improved endothelial dysfunction, and reduced oxidative stress and infl ...[more]