Design and Characterization of a Novel Blood Collection and Transportation Device for Proteomic Applications.

ABSTRACT: A major hurdle for blood-based proteomic diagnostics is efficient transport of specimens from the collection site to the testing laboratory. Dried blood spots have shown utility for diagnostic applications, specifically those where red blood cell hemolysis and contamination of specimens with hemoglobin is not confounding. Conversely, applications that are sensitive to the presence of the hemoglobin subunits require blood separation, which relies on centrifugation to collect plasma/serum, and then cold-chain custody during shipping. All these factors introduce complexities and potentially increased costs. Here we report on a novel whole blood-collection device (BCD) that efficiently separates the liquid from cellular components, minimizes hemolysis in the plasma fraction, and maintains prot

SUBMITTER: Kaiser NK 

PROVIDER: S-EPMC7761483 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature