Ontology highlight
ABSTRACT:
SUBMITTER: Kutova OM
PROVIDER: S-EPMC7761996 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Kutova Olga M OM Sencha Ludmila M LM Pospelov Anton D AD Dobrynina Olga E OE Brilkina Anna A AA Cherkasova Elena I EI Balalaeva Irina V IV
Biology 20201204 12
Tumor resistance to therapy is associated with the 3D organization and peculiarities of the tumor microenvironment, of which intercellular adhesion is a key participant. In this work, the abundance of contact proteins was compared in SKOV-3 and SKOV-3.ip human ovarian adenocarcinoma cell lines, cultivated in monolayers, tumor spheroids and collagen hydrogels. Three-dimensional models were characterized by extremely low expression of basic molecules of adherens junctions E-cadherin and demonstrat ...[more]