Ontology highlight
ABSTRACT:
SUBMITTER: Hirschhauser C
PROVIDER: S-EPMC7762598 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Hirschhäuser Christine C Sydykov Akylbek A Wolf Annemarie A Esfandiary Azadeh A Bornbaum Julia J Kutsche Hanna Sarah HS Boengler Kerstin K Sommer Natascha N Schreckenberg Rolf R Schlüter Klaus-Dieter KD Weissmann Norbert N Schermuly Ralph R Schulz Rainer R
International journal of molecular sciences 20201208 24
The leading cause of death in pulmonary arterial hypertension (PAH) is right ventricular (RV) failure (RVF). Reactive oxygen species (ROS) have been suggested to play a role in the development of RV hypertrophy (RVH) and the transition to RVF. The hydrogen peroxide-generating protein p66shc has been associated with left ventricular (LV) hypertrophy but its role in RVH is unclear. The purpose of this study was to determine whether genetic deletion of p66shc affects the development and/or progress ...[more]