Ontology highlight
ABSTRACT:
SUBMITTER: Chan JA
PROVIDER: S-EPMC7762767 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Chan Jo-Anne JA Loughland Jessica R JR de Labastida Rivera Fabian F SheelaNair Arya A Andrew Dean W DW Dooley Nicholas L NL Wines Bruce D BD Amante Fiona H FH Webb Lachlan L Hogarth P Mark PM McCarthy James S JS Beeson James G JG Engwerda Christian R CR Boyle Michelle J MJ
Cell reports. Medicine 20201222 9
CD4<sup>+</sup> T follicular helper cells (Tfh) are key drivers of antibody development. During <i>Plasmodium falciparum</i> malaria in children, the activation of Tfh is restricted to the Th1 subset and not associated with antibody levels. To identify Tfh subsets that are associated with antibody development in malaria, we assess Tfh and antibodies longitudinally in human volunteers with experimental <i>P. falciparum</i> infection. Tfh cells activate during infection, with distinct dynamics in ...[more]