Ontology highlight
ABSTRACT:
SUBMITTER: Hassan SS
PROVIDER: S-EPMC7763092 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20201213 24
Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different sp ...[more]