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Association of the Amount and Pattern of Physical Activity With Arterial Stiffness: The Maastricht Study.

ABSTRACT: Background Arterial stiffness is an independent risk factor for cardiovascular disease and can be beneficially influenced by physical activity. However, it is not clear how an individual's physical activity pattern over a week is associated with arterial stiffness. Therefore, we examined the associations of the amount and pattern of higher intensity physical activity with arterial stiffness. Methods and Results Data from the Maastricht Study (n=1699; mean age: 60±8 years, 49.4% women, 26.9% type 2 diabetes mellitus) were used. Arterial stiffness was assessed by carotid-to-femoral pulse wave velocity and carotid distensibility. The amount (continuous variable as h/wk) and pattern (categorical variable) of higher intensity physical activity were assessed with the activPAL3. Activity groups were: inactive (<75 min/wk), insufficiently active (75-150 min/wk), weekend warrior (>150 min/wk in ?2 sessions), and regularly active (>150 min/wk in ?3 sessions). In the fully adjusted model (adjusted for demographic, lifestyle, and cardiovascular risk factors), higher intensity physical activity was associated with lower carotid-to-femoral pulse wave velocity (amount: ? = -0.05, 95% CI, -0.09 to -0.01; insufficiently active: ? = -0.33, 95% CI, -0.55 to -0.11; weekend warrior: ? = -0.38, 95% CI, -0.64 to -0.12; and regularly active: ? = -0.46, 95% CI, -0.71 to -0.21 [reference: inactive]). These associations were stronger in those with type 2 diabetes mellitus. There was no statistically significant association between higher intensity physical activity with carotid distensibility. Conclusions Participating in higher intensity physical activity was associated with lower carotid-to-femoral pulse wave velocity, but there was no difference between the regularly actives and the weekend warriors. From the perspective of arterial stiffness, engaging higher intensity physical activity, regardless of the weekly pattern, may be an important strategy to reduce the risk of cardiovascular disease, particularly in individuals with type 2 diabetes mellitus.

SUBMITTER: Vandercappellen EJ

PROVIDER: S-EPMC7763372 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Association of the Amount and Pattern of Physical Activity With Arterial Stiffness: The Maastricht Study.

Vandercappellen Evelien J EJ Henry Ronald M A RMA Savelberg Hans H C M HHCM van der Berg Julianne D JD Reesink Koen D KD Schaper Nicolaas C NC Eussen Simone J P M SJPM van Dongen Martien C J M MCJM Dagnelie Pieter C PC Schram Miranda T MT van Greevenbroek Marleen M J MMJ Wesselius Anke A van der Kallen Carla J H CJH Köhler Sebastian S Stehouwer Coen D A CDA Koster Annemarie A

Journal of the American Heart Association 20201015 20

Background Arterial stiffness is an independent risk factor for cardiovascular disease and can be beneficially influenced by physical activity. However, it is not clear how an individual's physical activity pattern over a week is associated with arterial stiffness. Therefore, we examined the associations of the amount and pattern of higher intensity physical activity with arterial stiffness. Methods and Results Data from the Maastricht Study (n=1699; mean age: 60±8 years, 49.4% women, 26.9% type ...[more]

PMID: 33054610

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Project description:BackgroundChronic kidney disease, which is defined as having a reduced kidney function (estimated glomerular filtration rate (eGFR)) and/or signs of kidney damage (albuminuria), is highly prevalent in Western society and is associated with adverse health outcomes, such as cardiovascular disease. This warrants a search for risk factors of lower eGFR and higher albuminuria. Physical activity and sedentary behavior may be such risk factors.ObjectiveTo examine associations of physical activity (total, high, low), sedentary time and sedentary behavior patterns (breaks, prolonged bouts, average bout duration) with eGFR and albuminuria.MethodsWe examined these associations in 2,258 participants of the Maastricht Study (average age 60.1±8.1 years; 51.3% men), who wore an accelerometer 24h/day on 7 consecutive days. Associations with continuous eGFR and categories of urinary albumin excretion (UAE; <15 [reference category], 15-<30, ?30 mg/24h) were evaluated with linear regression analyses and multinomial logistic regression analyses, respectively.ResultsAfter adjustment for potential confounders, each extra hour of total physical activity was associated with a more favorable kidney function (betaeGFR = 2.30 (95%CI = 1.46; 3.14)), whereas each extra hour of sedentary behavior was associated with a more adverse kidney function (betaeGFR = -0.71 (-1.08; -0.35)). Also, compared to individuals with the lowest levels of total physical activity, individuals with the highest levels had less kidney damage (OR15-<30mg/24h = 0.63 (0.41; 0.96), OR?30mg/24h = 0.84 (0.53; 1.35). An extra hour of sedentary behavior was associated with more kidney damage (OR15-<30 mg/24h = 1.11 (1.01; 1.22), OR?30 mg/24h = 1.10 (0.99; 1.22)). Further, a highly sedentary pattern was associated with a more adverse kidney function, but no association was seen with kidney damage.ConclusionsPhysical activity and sedentary behavior were associated with kidney function and kidney damage. Additionally, sedentary behavior patterns were associated with kidney function. Causal studies are required to examine whether this indeed implicates that prevention strategies should focus not only on increasing physical activity, but on reducing sedentary behavior as well.

Dataset Information

Association of the Amount and Pattern of Physical Activity With Arterial Stiffness: The Maastricht Study.

Publications

Association of the Amount and Pattern of Physical Activity With Arterial Stiffness: The Maastricht Study.

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