Ontology highlight
ABSTRACT:
SUBMITTER: Fuentes-Baile M
PROVIDER: S-EPMC7763458 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Fuentes-Baile María M Ventero María P MP Encinar José A JA García-Morales Pilar P Poveda-Deltell María M Pérez-Valenciano Elizabeth E Barberá Víctor M VM Gallego-Plazas Javier J Rodríguez-Lescure Álvaro Á Martín-Nieto José J Saceda Miguel M
Cancers 20201211 12
We have determined the effects of the IGF-1R tyrosine kinase inhibitors BMS-754807 (BMS) and OSI-906 (OSI) on cell proliferation and cell-cycle phase distribution in human colon, pancreatic carcinoma, and glioblastoma cell lines and primary cultures. IGF-1R signaling was blocked by BMS and OSI at equivalent doses, although both inhibitors exhibited differential antiproliferative effects. In all pancreatic carcinoma cell lines tested, BMS exerted a strong antiproliferative effect, whereas OSI had ...[more]