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PDI Family Members as Guides for Client Folding and Assembly.

ABSTRACT: Complicated and sophisticated protein homeostasis (proteostasis) networks in the endoplasmic reticulum (ER), comprising disulfide catalysts, molecular chaperones, and their regulators, help to maintain cell viability. Newly synthesized proteins inserted into the ER need to fold and assemble into unique native structures to fulfill their physiological functions, and this is assisted by protein disulfide isomerase (PDI) family. Herein, we focus on recent advances in understanding the detailed mechanisms of PDI family members as guides for client folding and assembly to ensure the efficient production of secretory proteins.

SUBMITTER: Kanemura S

PROVIDER: S-EPMC7763558 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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PDI Family Members as Guides for Client Folding and Assembly.

Kanemura Shingo S Matsusaki Motonori M Inaba Kenji K Okumura Masaki M

International journal of molecular sciences 20201208 24

Complicated and sophisticated protein homeostasis (proteostasis) networks in the endoplasmic reticulum (ER), comprising disulfide catalysts, molecular chaperones, and their regulators, help to maintain cell viability. Newly synthesized proteins inserted into the ER need to fold and assemble into unique native structures to fulfill their physiological functions, and this is assisted by protein disulfide isomerase (PDI) family. Herein, we focus on recent advances in understanding the detailed mech ...[more]

PMID: 33302492

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