Ontology highlight
ABSTRACT:
SUBMITTER: Mittal P
PROVIDER: S-EPMC7763565 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Mittal Payal P Wang Liqing L Akimova Tatiana T Leach Craig A CA Clemente Jose C JC Sender Matthew R MR Chen Yao Y Turunen Brandon J BJ Hancock Wayne W WW
Cancers 20201211 12
Host anti-tumor immunity can be hindered by various mechanisms present within the tumor microenvironment, including the actions of myeloid-derived suppressor cells (MDSCs). We investigated the role of the CCR2/MCP-1 pathway in MDSC-associated tumor progression in murine lung cancer models. Phenotypic profiling revealed maximal expression of CCR2 by tumor-resident MDSCs, and MCP-1 by transplanted TC1 tumor cells, respectively. Use of CCR2-knockout (CCR2-KO) mice showed dependence of tumor growth ...[more]