CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate.
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ABSTRACT:
SUBMITTER: Stolarova L
PROVIDER: S-EPMC7763663 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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<i>CHEK2</i> Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate.
Stolarova Lenka L Kleiblova Petra P Janatova Marketa M Soukupova Jana J Zemankova Petra P Macurek Libor L Kleibl Zdenek Z
Cells 20201212 12
Germline alterations in many genes coding for proteins regulating DNA repair and DNA damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as pathogenic factors in hereditary cancer predisposition. The ATM-CHEK2-p53 axis has been documented as a backbone for DDR and hypothesized as a barrier against cancer initiation. However, although CHK2 kinase coded by the <i>CHEK2</i> gene expedites the DDR signal, its function in activation of p53-dependent cell cycle arrest is disp ...[more]
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