Ontology highlight
ABSTRACT:
SUBMITTER: Takayanagi Y
PROVIDER: S-EPMC7764148 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Takayanagi Yuhei Y Kikuchi Takeshi T Hasegawa Yoshiaki Y Naiki Yoshikazu Y Goto Hisashi H Okada Kousuke K Okabe Iichiro I Kamiya Yosuke Y Suzuki Yuki Y Sawada Noritaka N Okabe Teppei T Suzuki Yuki Y Kondo Shun S Ohno Tasuku T Hayashi Jun-Ichiro JI Mitani Akio A
Journal of clinical medicine 20201210 12
<i>Porphyromonas gingivalis</i> Mfa1 fimbriae are thought to act as adhesion factors and to direct periodontal tissue destruction but their immunomodulatory actions are poorly understood. Here, we investigated the effect of Mfa1 stimulation on the immune and metabolic mechanisms of gingival fibroblasts from periodontal connective tissue. We also determined the role of Toll-like receptor (TLR) 2 and TLR4 in Mfa1 recognition. Mfa1 increased the expression of genes encoding chemokine (C-X-C motif) ...[more]