Ontology highlight
ABSTRACT:
SUBMITTER: Klomp F
PROVIDER: S-EPMC7764576 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Klomp Florian F Wenzel Christoph C Drozdzik Marek M Oswald Stefan S
Pharmaceutics 20201211 12
Cytochrome P450 (CYP) 1A enzymes are considerably expressed in the human intestine and liver and involved in the biotransformation of about 10% of marketed drugs. Despite this doubtless clinical relevance, CYP1A1 and CYP1A2 are still somewhat underestimated in terms of unwanted side effects and drug-drug interactions of their respective substrates. In contrast to this, many frequently prescribed drugs that are subjected to extensive CYP1A-mediated metabolism show a narrow therapeutic index and s ...[more]