Ontology highlight
ABSTRACT:
SUBMITTER: Bruno E
PROVIDER: S-EPMC7764681 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Bruno Eleonora E Oliverio Andreina A Paradiso Angelo Virgilio AV Daniele Antonella A Tommasi Stefania S Tufaro Antonio A Terribile Daniela Andreina DA Magno Stefano S Filippone Alessio A Venturelli Elisabetta E Morelli Daniele D Baldassari Ivan I Cravana Maria Luisa ML Manoukian Siranoush S Pasanisi Patrizia P
Cancers 20201211 12
<i>Background:</i> Women carriers of <i>BRCA1</i>/<i>2</i> mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of B ...[more]