Dataset Information

Impact of BRCA Mutation Status on Tumor Infiltrating Lymphocytes (TILs), Response to Treatment, and Prognosis in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy.

ABSTRACT:

Introduction

Five to 10% of breast cancers (BCs) occur in a genetic predisposition context (mainly BRCA pathogenic variant). Nevertheless, little is known about immune tumor infiltration, response to neoadjuvant chemotherapy (NAC), pathologic complete response (pCR) and adverse events according to BRCA status.

Material and methods

Out of 1199 invasive BC patients treated with NAC between 2002 and 2012, we identified 267 patients tested for a germline BRCA pathogenic variant. We evaluated pre-NAC and post-NAC immune infiltration (TILs). Response to chemotherapy was assessed by pCR rates. Association of clinical and pathological factors with TILs, pCR and survival was assessed by univariate and multivariate analyses.

Results

Among 1199 BC patients: 46 were BRCA-deficient and 221 BRCA-proficient or wild type (WT). At NAC completion, pCR was observed in 84/266 (31%) patients and pCR rates were significantly higher in BRCA-deficient BC (p = 0.001), and this association remained statistically significant only in the luminal BC subtype (p = 0.006). The interaction test between BC subtype and BRCA status was nearly significant (P_interaction = 0.056). Pre and post-NAC TILs were not significantly different between BRCA-deficient and BRCA-proficient carriers; however, in the luminal BC group, post-NAC TILs were significantly higher in BRCA-deficient BC. Survival analysis were not different between BRCA-carriers and non-carriers.

Conclusions

BRCA mutation status is associated with higher pCR rates and post-NAC TILs in patients with luminal BC. BRCA-carriers with luminal BCs may represent a subset of patients deriving higher benefit from NAC. Second line therapies, including immunotherapy after NAC, could be of interest in non-responders to NAC.

SUBMITTER: Grandal B

PROVIDER: S-EPMC7764707 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Publications

Impact of <i>BRCA</i> Mutation Status on Tumor Infiltrating Lymphocytes (TILs), Response to Treatment, and Prognosis in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy.

Grandal Beatriz B Evrevin Clémence C Laas Enora E Jardin Isabelle I Rozette Sonia S Laot Lucie L Dumas Elise E Coussy Florence F Pierga Jean-Yves JY Brain Etienne E Saule Claire C Stoppa-Lyonnet Dominique D Frank Sophie S Sénéchal Claire C Lae Marick M De Croze Diane D Bataillon Guillaume G Guerin Julien J Reyal Fabien F Hamy Anne-Sophie AS

Cancers 20201208 12

<h4>Introduction</h4>Five to 10% of breast cancers (BCs) occur in a genetic predisposition context (mainly <i>BRCA</i> pathogenic variant). Nevertheless, little is known about immune tumor infiltration, response to neoadjuvant chemotherapy (NAC), pathologic complete response (pCR) and adverse events according to <i>BRCA</i> status.<h4>Material and methods</h4>Out of 1199 invasive BC patients treated with NAC between 2002 and 2012, we identified 267 patients tested for a germline <i>BRCA</i> path ...[more]

PMID: 33302444

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