Ontology highlight
ABSTRACT:
SUBMITTER: Geraud A
PROVIDER: S-EPMC7764991 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Geraud Arthur A Mezquita Laura L Auclin Edouard E Combarel David D Delahousse Julia J Gougis Paul P Massard Christophe C Jovelet Cécile C Caramella Caroline C Adam Julien J Naltet Charles C Lavaud Pernelle P Gazzah Anas A Lacroix Ludovic L Rouleau Etienne E Vasseur Damien D Mir Olivier O Planchard David D Paci Angelo A Besse Benjamin B
Cancers 20201214 12
Kinase inhibitors (KI) have dramatically improved the outcome of treatment in patients with non-small cell lung cancer (NSCLC), which harbors an oncogene addiction. This study assesses KI plasma levels and their clinical relevance in patients chronically exposed to KIs. Plasma samples were collected in NSCLC patients receiving erlotinib, gefitinib, osimertinib, crizotinib, or dabrafenib (with or without trametinib) for at least three months between November 2013 and February 2019 in a single ins ...[more]