A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function.
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ABSTRACT:
SUBMITTER: Zampino M
PROVIDER: S-EPMC7765442 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function.
Zampino Marta M Tanaka Toshiko T Ubaida-Mohien Ceereena C Fantoni Giovanna G Candia Julián J Semba Richard D RD Ferrucci Luigi L
International journal of molecular sciences 20201215 24
Although mitochondrial dysfunction has been implicated in aging, physical function decline, and several age-related diseases, an accessible and affordable measure of mitochondrial health is still lacking. In this study we identified the proteomic signature of muscular mitochondrial oxidative capacity in plasma. In 165 adults, we analyzed the association between concentrations of plasma proteins, measured using the SOMAscan assay, and skeletal muscle maximal oxidative phosphorylation capacity ass ...[more]
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