Dataset Information

Comparative Pathogenomics of Aeromonas veronii from Pigs in South Africa: Dominance of the Novel ST657 Clone.

ABSTRACT: The pathogenomics of carbapenem-resistant Aeromonas veronii (A. veronii) isolates recovered from pigs in KwaZulu-Natal, South Africa, was explored by whole genome sequencing on the Illumina MiSeq platform. Genomic functional annotation revealed a vast array of similar central networks (metabolic, cellular, and biochemical). The pan-genome analysis showed that the isolates formed a total of 4349 orthologous gene clusters, 4296 of which were shared; no unique clusters were observed. All the isolates had similar resistance phenotypes, which corroborated their chromosomally mediated resistome (bla_CPHA₃ and bla_OXA-₁₂) and belonged to a novel sequence type, ST657 (a satellite clone). Isolates in the same sub-clades clustered according to their clonal lineages and host. Mobilome analysis revealed the presence of chromosome-borne insertion sequence families. The estimated pathogenicity score (P_score ? 0.60) indicated their potential pathogenicity in humans. Furthermore, these isolates carried several virulence factors (adherence factors, toxins, and immune evasion), in different permutations and combinations, indicating a differential ability to establish infection. Phylogenomic and metadata analyses revealed a predilection for water environments and aquatic animals, with more recent reports in humans and food animals across geographies, making A. veronii a potential One Health indicator bacterium.

SUBMITTER: Ramsamy Y

PROVIDER: S-EPMC7765573 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Publications

Comparative Pathogenomics of <i>Aeromonas veronii</i> from Pigs in South Africa: Dominance of the Novel ST657 Clone.

Ramsamy Yogandree Y Mlisana Koleka P KP Amoako Daniel G DG Abia Akebe Luther King ALK Allam Mushal M Ismail Arshad A Singh Ravesh R Essack Sabiha Y SY

Microorganisms 20201216 12

The pathogenomics of carbapenem-resistant <i>Aeromonas veronii (A. veronii)</i> isolates recovered from pigs in KwaZulu-Natal, South Africa, was explored by whole genome sequencing on the Illumina MiSeq platform. Genomic functional annotation revealed a vast array of similar central networks (metabolic, cellular, and biochemical). The pan-genome analysis showed that the isolates formed a total of 4349 orthologous gene clusters, 4296 of which were shared; no unique clusters were observed. All the ...[more]

PMID: 33339176

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Dataset Information

Comparative Pathogenomics of Aeromonas veronii from Pigs in South Africa: Dominance of the Novel ST657 Clone.

Publications

Comparative Pathogenomics of <i>Aeromonas veronii</i> from Pigs in South Africa: Dominance of the Novel ST657 Clone.

Similar Datasets

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