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New Cyclic Diarylheptanoids from Platycarya strobilacea.

ABSTRACT: Five new cyclic diarylheptanoids (platycary A-E, compounds 1-5) and three previously identified analogues (i.e., phttyearynol (compound 6), myricatomentogenin (compound 7), and juglanin D (compound 8)) were isolated from the stem bark of Platycarya strobilacea. The structures of these compounds were determined using NMR, HRESIMS, and electronic circular dichroism (ECD) data. The cytotoxicity of compounds 1-5 and their ability to inhibit nitric oxide (NO) production, as well as protect against the corticosterone-induced apoptosis of Pheochromocytoma (PC12) cells, were evaluated in vitro using the appropriate bioassays. Compounds 1 and 2 significantly inhibited the corticosterone-induced apoptosis of PC12 cells at a concentration of 20 ??.

SUBMITTER: Ding WB

PROVIDER: S-EPMC7766178 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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New Cyclic Diarylheptanoids from Platycarya strobilacea.

Ding Wen-Bing WB Zhao Rui-Yuan RY Li Guan-Hua GH Liu Bing-Lei BL He Hua-Liang HL Qiu Lin L Xue Jin J Li You-Zhi YZ

Molecules (Basel, Switzerland) 20201220 24

Five new cyclic diarylheptanoids (platycary A-E, compounds 1-5) and three previously identified analogues (i.e., phttyearynol (compound 6), myricatomentogenin (compound 7), and juglanin D (compound 8)) were isolated from the stem bark of Platycarya strobilacea. The structures of these compounds were determined using NMR, HRESIMS, and electronic circular dichroism (ECD) data. The cytotoxicity of compounds 1-5 and their ability to inhibit nit ...[more]

PMID: 33419270

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Platycarya strobilacea

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