Ontology highlight
ABSTRACT:
SUBMITTER: Dergilev KV
PROVIDER: S-EPMC7766731 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Dergilev Konstantin V KV Shevchenko Evgeny K EK Tsokolaeva Zoya I ZI Beloglazova Irina B IB Zubkova Ekaterina S ES Boldyreva Maria A MA Menshikov Mikhail Yu MY Ratner Elizaveta I EI Penkov Dmitry D Parfyonova Yelena V YV
International journal of molecular sciences 20201216 24
Cell therapy of the post-infarcted myocardium is still far from clinical use. Poor survival of transplanted cells, insufficient regeneration, and replacement of the damaged tissue limit the potential of currently available cell-based techniques. In this study, we generated a multilayered construct from adipose-derived mesenchymal stromal cells (MSCs) modified to secrete stem cell factor, SCF. In a rat model of myocardium infarction, we show that transplantation of SCF producing cell sheet induce ...[more]