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A Comparative View on the Oviductal Environment during the Periconception Period.

ABSTRACT: The oviduct plays important roles in reproductive events: sperm reservoir formation, final gamete maturation, fertilization and early embryo development. It is well known that the oviductal environment affects gametes and embryos and, ultimately, the health of offspring, so that in vivo embryos are better in terms of morphology, cryotolerance, pregnancy rates or epigenetic profile than those obtained in vitro. The deciphering of embryo-maternal interaction in the oviduct may provide a better understanding of the embryo needs during the periconception period to improve reproductive efficiency. Here, we perform a comparative analysis among species of oviductal gene expression related to embryonic development during its journey through the oviduct, as described to date. Cross-talk communication between the oviduct environment and embryo will be studied by analyses of the secreted or exosomal proteins of the oviduct and the presence of receptors in the membrane of the embryo blastomeres. Finally, we review the data that are available to date on the expression and characterization of the most abundant protein in the oviduct, oviductin (OVGP1), highlighting its fundamental role in fertilization and embryonic development.

SUBMITTER: Gonzalez-Brusi L

PROVIDER: S-EPMC7766821 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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A Comparative View on the Oviductal Environment during the Periconception Period.

González-Brusi Leopoldo L Algarra Blanca B Moros-Nicolás Carla C Izquierdo-Rico Mª José MJ Avilés Manuel M Jiménez-Movilla Maria M

Biomolecules 20201217 12

The oviduct plays important roles in reproductive events: sperm reservoir formation, final gamete maturation, fertilization and early embryo development. It is well known that the oviductal environment affects gametes and embryos and, ultimately, the health of offspring, so that in vivo embryos are better in terms of morphology, cryotolerance, pregnancy rates or epigenetic profile than those obtained in vitro. The deciphering of embryo-maternal interaction in the oviduct may provide a better und ...[more]

PMID: 33348856

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Project description:BACKGROUND:The incidence of CHD is the highest among birth defects and is increasing year to year. CHD seriously harms the health of infants and young children and presents a large economic burden to families and society. The pathogenesis of CHD and preventive measures are the focus of current research. Our research aimed to explore the intervention effect of folic acid on heart abnormalities resulting from sodium arsenic (NaAsO2) exposure during the periconception period. METHODS:Sixty 35-day-old female SD rats were randomly divided into 5 groups with 12 rats in each group. Group A was the control group. The rats were given distilled water and ordinary chow. The rats in group B were given distilled water containing 75?mg/L NaAsO2 and ordinary chow. The rats in groups C, D, and E were given distilled water containing 75?mg/L NaAsO2 and chow containing 0.53?mg/kg, 5.3?mg/kg, and 10.6?mg/kg folic acid, respectively. The general condition of the embryos and the histopathology of the embryonic hearts were examined. The acetylation levels of histone H3K9 in heart tissues and the expression levels of Mef2C (which is related to heart development) were observed. RESULTS:The embryo weight and placental weight of groups B-E were significantly lower than those of group A (P?<?0.05). The heart malformation rate of the fetal rats in groups B-E was significantly higher than that of the fetal rats in group A (P?<?0.05). We found that the level of H3K9 acetylation in fetal rat cardiomyocytes in groups B-E was significantly higher than that in group A (P?<?0.05) and that the level of H3K9 acetylation in groups C-E was lower than that in group B (P?<?0.05). The mRNA level of Mef2C in fetal rat cardiomyocytes in group B-E was significantly higher than that in group A (P?<?0.05), and the mRNA level of Mef2C in groups C-E was significantly lower than that in group B (P?<?0.05). CONCLUSION:Supplementation with folic acid during the periconception period can interfere with the toxic effects of arsenic on the heart. The mechanism may be that lowering the acetylation levels of histone H3K9 in heart tissues leads to decreased expression levels of Mef2C, which may play a protective role in heart development in fetal rats.

Dataset Information

A Comparative View on the Oviductal Environment during the Periconception Period.

Publications

A Comparative View on the Oviductal Environment during the Periconception Period.

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