The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases.
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SUBMITTER: Todd AC
PROVIDER: S-EPMC7766851 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases.
Todd Alison C AC Hardingham Giles E GE
International journal of molecular sciences 20201217 24
The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels at low levels. In physiology, this is essential for the rapid uptake of synaptically released glutamate, maintaining the temporal fidelity of synaptic transmission. However, EAAT1/2 hypo-expression or hypo-function are implicated in several disorders, including epilepsy and neurodegenerative diseases, as well as b ...[more]
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