Ontology highlight
ABSTRACT:
SUBMITTER: Sahnane N
PROVIDER: S-EPMC7767143 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Sahnane Nora N Carnevali Ileana I Formenti Giorgio G Casarin Jvan J Facchi Sofia S Bombelli Raffaella R Di Lauro Eleonora E Memoli Domenico D Salvati Annamaria A Rizzo Francesca F Sessa Fausto F Tibiletti Maria Grazia MG
International journal of molecular sciences 20201219 24
Homologous Recombination Deficiency (HRD) is a frequent feature of high-grade epithelial ovarian carcinoma (EOC), associated with sensitivity to PARP-inhibitors (PARPi). The best characterized causes of HRD in EOCs are germline or somatic mutations in <i>BRCA1</i> and <i>BRCA2</i> genes. Although promoter methylation is a well-known mechanism of gene transcriptional repression, few data have been published about <i>BRCA</i> gene methylation in EOCs. In this retrospective study, we quantitatively ...[more]