Dataset Information

Targeting Glycans and Heavily Glycosylated Proteins for Tumor Imaging.

ABSTRACT: Real-time tumor imaging techniques are increasingly used in oncological surgery, but still need to be supplemented with novel targeted tracers, providing specific tumor tissue detection based on intra-tumoral processes or protein expression. To maximize tumor/non-tumor contrast, targets should be highly and homogenously expressed on tumor tissue only, preferably from the earliest developmental stage onward. Unfortunately, most evaluated tumor-associated proteins appear not to meet all of these criteria. Thus, the quest for ideal targets continues. Aberrant glycosylation of proteins and lipids is a fundamental hallmark of almost all cancer types and contributes to tumor progression. Additionally, overexpression of glycoproteins that carry aberrant glycans, such as mucins and proteoglycans, is observed. Selected tumor-associated glyco-antigens are abundantly expressed and could, thus, be ideal candidates for targeted tumor imaging. Nevertheless, glycan-based tumor imaging is still in its infancy. In this review, we highlight the potential of glycans, and heavily glycosylated proteoglycans and mucins as targets for multimodal tumor imaging by discussing the preclinical and clinical accomplishments within this field. Additionally, we describe the major advantages and limitations of targeting glycans compared to cancer-associated proteins. Lastly, by providing a brief overview of the most attractive tumor-associated glycans and glycosylated proteins in association with their respective tumor types, we set out the way for implementing glycan-based imaging in a clinical practice.

SUBMITTER: Houvast RD

PROVIDER: S-EPMC7767531 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Targeting Glycans and Heavily Glycosylated Proteins for Tumor Imaging.

Houvast Ruben D RD Vankemmelbeke Mireille M Durrant Lindy G LG Wuhrer Manfred M Baart Victor M VM Kuppen Peter J K PJK de Geus-Oei Lioe-Fee LF Vahrmeijer Alexander L AL Sier Cornelis F M CFM

Cancers 20201221 12

Real-time tumor imaging techniques are increasingly used in oncological surgery, but still need to be supplemented with novel targeted tracers, providing specific tumor tissue detection based on intra-tumoral processes or protein expression. To maximize tumor/non-tumor contrast, targets should be highly and homogenously expressed on tumor tissue only, preferably from the earliest developmental stage onward. Unfortunately, most evaluated tumor-associated proteins appear not to meet all of these c ...[more]

PMID: 33371487

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Dataset Information

Targeting Glycans and Heavily Glycosylated Proteins for Tumor Imaging.

Publications

Targeting Glycans and Heavily Glycosylated Proteins for Tumor Imaging.

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