Ontology highlight
ABSTRACT:
SUBMITTER: Upadhyay M
PROVIDER: S-EPMC7767746 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Upadhyay Mala M Milliner Caroline C Bell Brent A BA Bonilha Vera L VL
Redox biology 20200717
High levels of oxidative radicals generated by daily light exposure and high metabolic rate suggest that the antioxidant machinery of the retina and retinal pigment epithelium (RPE) is crucial for their survival. DJ-1 is a redox-sensitive protein that has been shown to have neuroprotective function in the brain in Parkinson's disease and other neurodegenerative diseases. Here, we analyzed the role of DJ-1 in the retina during oxidative stress and aging. We induced low-level oxidative stress in y ...[more]