Ontology highlight
ABSTRACT: Purpose
This study addresses the need for a global cancer patient-based standard population that adjusts for the expected age structure of different cancers, thus aiding the comparison of survival estimates worldwide.Methods
Counts of age-specific incidence for 36 cancer sites in 185 countries for the year 2018 were extracted from IARC's GLOBOCAN database of national estimates. We used a multinomial mixture regression to identify clusters of cancer sites with similar age-specific profiles.Results
An updated standard entitled the World Cancer Patient Population (WCPP) is presented, derived from the current estimated global numbers of cancer patients that comprises three sets of age-specific weights. Around two-thirds of cancer sites were described by a unique standard, representing the majority of epithelial cancers more often diagnosed at older age groups. The two other standards represent a number of non-epithelial cancer types, and cancers common at younger and older age groups, respectively.Conclusion
The WCPP proposed here provides a contemporary and global means to estimate age-standardised survival for international benchmarking purposes.
SUBMITTER: Miranda-Filho A
PROVIDER: S-EPMC7768180 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Miranda-Filho Adalberto A Bray Freddie F Charvat Hadrien H Rajaraman Swaminathan S Soerjomataram Isabelle I
Cancer epidemiology 20200914
<h4>Purpose</h4>This study addresses the need for a global cancer patient-based standard population that adjusts for the expected age structure of different cancers, thus aiding the comparison of survival estimates worldwide.<h4>Methods</h4>Counts of age-specific incidence for 36 cancer sites in 185 countries for the year 2018 were extracted from IARC's GLOBOCAN database of national estimates. We used a multinomial mixture regression to identify clusters of cancer sites with similar age-specific ...[more]