Brain development in children with developmental delay using amide proton transfer-weighted imaging and magnetization transfer imaging.

ABSTRACT:

Importance

The process of brain development in children with developmental delay is not well known. Amide proton transfer-weighted (APTw) imaging is a novel molecular magnetic resonance imaging (MRI) technique that can noninvasively detect cytosolic endogenous mobile proteins and peptides involved in the myelination process, and may be useful for providing insights into brain development.

Objective

To assess the contribution of amide proton transfer-weighted (APTw) imaging and magnetization transfer (MT) imaging to the evaluation of children with developmental delay (DD).

Methods

Fifty-one patients with DD were recruited to this study. The patients were divided into two groups according to the state of myelination assessed on conventional magnetic resonance imaging (M

SUBMITTER: Tang X 

PROVIDER: S-EPMC7768295 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature