Dataset Information

Effect of APOE ?4 on multimodal brain connectomic traits: a persistent homology study.

ABSTRACT:

Background

Although genetic risk factors and network-level neuroimaging abnormalities have shown effects on cognitive performance and brain atrophy in Alzheimer's disease (AD), little is understood about how apolipoprotein E (APOE) ?4 allele, the best-known genetic risk for AD, affect brain connectivity before the onset of symptomatic AD. This study aims to investigate APOE ?4 effects on brain connectivity from the perspective of multimodal connectome.

Results

Here, we propose a novel multimodal brain network modeling framework and a network quantification method based on persistent homology for identifying APOE ?4-related network differences. Specifically, we employ sparse representation to integrate multimodal brain network information derived from both the resting state functional magnetic resonance imaging (rs-fMRI) data and the diffusion-weighted magnetic resonance imaging (dw-MRI) data. Moreover, persistent homology is proposed to avoid the ad hoc selection of a specific regularization parameter and to capture valuable brain connectivity patterns from the topological perspective. The experimental results demonstrate that our method outperforms the competing methods, and reasonably yields connectomic patterns specific to APOE ?4 carriers and non-carriers.

Conclusions

We have proposed a multimodal framework that integrates structural and functional connectivity information for constructing a fused brain network with greater discriminative power. Using persistent homology to extract topological features from the fused brain network, our method can effectively identify APOE ?4-related brain connectomic biomarkers.

SUBMITTER: Li J

PROVIDER: S-EPMC7768655 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Effect of APOE ε4 on multimodal brain connectomic traits: a persistent homology study.

Li Jin J Bian Chenyuan C Chen Dandan D Meng Xianglian X Luo Haoran H Liang Hong H Shen Li L

BMC bioinformatics 20201228 Suppl 21

<h4>Background</h4>Although genetic risk factors and network-level neuroimaging abnormalities have shown effects on cognitive performance and brain atrophy in Alzheimer's disease (AD), little is understood about how apolipoprotein E (APOE) ε4 allele, the best-known genetic risk for AD, affect brain connectivity before the onset of symptomatic AD. This study aims to investigate APOE ε4 effects on brain connectivity from the perspective of multimodal connectome.<h4>Results</h4>Here, we propose a n ...[more]

PMID: 33371873

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