Dataset Information

Lepidic component identifies a subgroup of lung adenocarcinoma with a distinctive prognosis: a multicenter propensity-matched analysis.

ABSTRACT:

Background

Our aim was to investigate the prognostic impact of the lepidic component on T stage in patients with lung adenocarcinoma (LUAD).

Methods

A retrospective data set including 863 cases of LUAD with lepidic component and 856 cases without lepidic component was used to identify matched lepidic-positive and lepidic-negative cohorts (n?=?376 patients per group) using a propensity-score matching. Primary outcome variables included recurrence-free survival (RFS) and overall survival (OS). Prognostic factors were assessed by Cox regression analysis and Kaplan-Meier estimates.

Results

Multivariate analysis revealed that lepidic component presence was an independent prognostic factor for prolonged RFS (p?p?25% or ?25% were confirmed to be independent prolonged survival predictors. No survival differences were observed between patients with LUAD with LR?>25% or ?25% (RFS p?=?0.333; OS p?=?0.078). The 5-year OS rates of patients with LUAD with a lepidic component were 90% regardless of the T stage, and these survival rates were significantly better than those of patients with LUAD without a lepidic component in the corresponding T stage. Multivariate analysis confirmed that T stage was associated with survival only in patients with LUAD without a lepidic component.

Conclusions

Lepidic component presence identifies a LUAD subgroup with an excellent prognosis independent of the LR, pathological T classification. Considering the lepidic component presence may improve prognostic predictions for patients with LUAD.

SUBMITTER: Zhu E

PROVIDER: S-EPMC7768877 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Lepidic component identifies a subgroup of lung adenocarcinoma with a distinctive prognosis: a multicenter propensity-matched analysis.

Zhu Erjia E Dai Chenyang C Xie Huikang H Su Hang H Hu Xuefei X Li Ming M Fan Junqiang J Liu Jinshi J Zhu Quan Q Zhang Lei L Ke Honggang H Chen Chang C

Therapeutic advances in medical oncology 20201223

<h4>Background</h4>Our aim was to investigate the prognostic impact of the lepidic component on T stage in patients with lung adenocarcinoma (LUAD).<h4>Methods</h4>A retrospective data set including 863 cases of LUAD with lepidic component and 856 cases without lepidic component was used to identify matched lepidic-positive and lepidic-negative cohorts (<i>n</i> = 376 patients per group) using a propensity-score matching. Primary outcome variables included recurrence-free survival (RFS) and over ...[more]

PMID: 33488781

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Dataset Information

Lepidic component identifies a subgroup of lung adenocarcinoma with a distinctive prognosis: a multicenter propensity-matched analysis.

Background

Methods

Results

Conclusions

Publications

Lepidic component identifies a subgroup of lung adenocarcinoma with a distinctive prognosis: a multicenter propensity-matched analysis.

Similar Datasets

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