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Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures.
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ABSTRACT: Background
The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI).Methods
Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated.Results
All patients had a high-level non-selective glomerular proteinuria. SARS-CoV-2 samples by real-time polymerase chain reaction (RT- PCR) assay were all-negative, as well as for virus particles in the kidney by electron microscopy. The three patients and patients with other AKI did not differ significantly with regard to angiotensin-converting enzyme 2 and transmembrane protease serine 2 kidney staining.Conclusions
The kidney damage particularly in Caucasians in COVID-19 seems to be an AKI, possibly by the systemic inflammatory response.
SUBMITTER: Dargelos M
PROVIDER: S-EPMC7769537 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures.
Clinical kidney journal 20201214 6
<h4>Background</h4>The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI).<h4>Methods</h4>Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated.<h4>Results</h4>All patients had a high-level non-selective glomerular proteinuria. SARS-CoV-2 samples by real-time polymerase chain reaction (RT- PCR) assay were all-negative, as well as for virus par ...[more]
