Ontology highlight
ABSTRACT:
SUBMITTER: Bridoux L
PROVIDER: S-EPMC7769617 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Bridoux Laure L Zarrineh Peyman P Mallen Joshua J Phuycharoen Mike M Latorre Victor V Ladam Frank F Losa Marta M Baker Syed Murtuza SM Sagerstrom Charles C Mace Kimberly A KA Rattray Magnus M Bobola Nicoletta N
PLoS genetics 20201214 12
Gene expression programs determine cell fate in embryonic development and their dysregulation results in disease. Transcription factors (TFs) control gene expression by binding to enhancers, but how TFs select and activate their target enhancers is still unclear. HOX TFs share conserved homeodomains with highly similar sequence recognition properties, yet they impart the identity of different animal body parts. To understand how HOX TFs control their specific transcriptional programs in vivo, we ...[more]