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BDNF Gene's Role in Schizophrenia: From Risk Allele to Methylation Implications.

ABSTRACT: Background: Schizophrenia (SZ) is a severe chronic mental disorder with complex genetic mechanisms. Brain-derived neurotrophic factor (BDNF) is one of promising candidate genes for SZ, and rs6265 is a non-synonymous single nucleotide polymorphism (SNP) in BDNF. Methods: In this study, we performed a case-control association study of rs6265 in a cohort of Han Chinese population from eastern China, including 1,407 SZ patients and 1,136 healthy controls; and carried out a cis-mQTL (Methylation Quantitative Trait Loci) analysis for BDNF rs6265. Results: We found a positive association of rs6265 with SZ (P = 0.037), with the minor allele (A) of rs6265 conferring a protecting effect for SZ (OR = 0.89). Furthermore, cis-mQTL analysis indicates that rs6265 is associated with several methylation loci surrounding BDNF. Conclusions: Together, our findings provide further evidence to support the involvement of BDNF gene in the genesis of SZ.

SUBMITTER: Fu X

PROVIDER: S-EPMC7769935 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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BDNF Gene's Role in Schizophrenia: From Risk Allele to Methylation Implications.

Fu Xiaoqian X Wang Jun J Du Jianbin J Sun Jing J Baranova Ancha A Zhang Fuquan F

Frontiers in psychiatry 20201215

<b>Background:</b> Schizophrenia (SZ) is a severe chronic mental disorder with complex genetic mechanisms. Brain-derived neurotrophic factor (BDNF) is one of promising candidate genes for SZ, and rs6265 is a non-synonymous single nucleotide polymorphism (SNP) in BDNF. <b>Methods:</b> In this study, we performed a case-control association study of rs6265 in a cohort of Han Chinese population from eastern China, including 1,407 SZ patients and 1,136 healthy controls; and carried out a cis-mQTL (Me ...[more]

PMID: 33384622

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BDNF gene role in schizophrenia: from risk allele to methylation implications

Project description:BDNF gene?s role in schizophrenia: from risk allele to methylation implications

2020-12-15 | PRJEB41532 | EVA

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