Ontology highlight
ABSTRACT:
SUBMITTER: Chen WC
PROVIDER: S-EPMC7770000 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Chen Wei-Chih WC Hu Gangqing G Hazlehurst Lori A LA
Current opinion in pharmacology 20200906
The bone marrow microenvironment (BMM) provides input via production of cytokines, chemokines, extracellular matrixes in the context of lower oxygen levels that influences self-renewal, survival, differentiation, progression, and therapeutic resistance of multiple myeloma and leukemic cells. Within the context of the BMM, tumor cells are supported by osteoblasts, bone marrow stromal cells (BMSCs), fibroblasts, myeloid cells, endothelial cells and blood vessels, as well as extracellular matrix (E ...[more]