Expression of Connexins 37, 43 and 45 in Developing Human Spinal Cord and Ganglia.

ABSTRACT: Direct intercellular communication via gap junctions has an important role in the development of the nervous system, ranging from cell migration and neuronal differentiation to the formation of neuronal activity patterns. This study characterized and compared the specific spatio-temporal expression patterns of connexins (Cxs) 37, 43 and 45 during early human developmental stages (since the 5th until the 10th developmental week) in the spinal cord (SC) and dorsal root ganglia (DRG) using double immunofluorescence and transmission electron microscopy. We found the expression of all three investigated Cxs during early human development in all the areas of interest, in the SC, DRG, developing paravertebral ganglia of the sympathetic trunk, notochord and all three meningeal layers, with predomi

SUBMITTER: Juric M 

PROVIDER: S-EPMC7770599 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature