Ontology highlight
ABSTRACT:
SUBMITTER: Tang Y
PROVIDER: S-EPMC7770760 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Tang Yuyang Y Woodward Beverly O BO Pastor Lorena L George Alvin M AM Petrechko Oksana O Nouvet Franklin J FJ Haas David W DW Jiang Guochun G Hildreth James E K JEK
Cell reports 20200301 13
Radical cure of HIV-1 (HIV) is hampered by the establishment of HIV reservoirs and persistent infection in deep tissues despite suppressive antiretroviral therapy (ART). Here, we show that among HIV-positive women receiving suppressive ART, cells from placental tissues including trophoblasts contain HIV RNA and DNA. These viruses can be reactivated by latency reversal agents. We find that syncytin, the envelope glycoprotein of human endogenous retrovirus family W1 expressed on placental trophobl ...[more]