Dataset Information

Sandwich-Like Fe&TiO₂@C Nanocomposites Derived from MXene/Fe-MOFs Hybrids for Electromagnetic Absorption.

ABSTRACT: Electromagnetic pollution has been causing a series of problems in people's life, and electromagnetic absorbers with lightweight and broad absorbing bandwidth properties are widely desired. In this work, novel sandwich-like 2D laminated Fe&TiO₂ nanoparticles@C nanocomposites were rationally designed and successfully developed from the MXene-MOFs hybrids. The formation of Fe and rutile-TiO₂ nanoparticles sandwiched by the two-dimensional carbon nanosheets provided strong electromagnetic energy attenuation and good impedance matching for electromagnetic wave (EMW) absorption. As expected, the nanocomposites achieved a broad effective absorption bandwidth of 6.5 GHz at a thickness of only 1.6 mm and the minimum reflection loss (RL) value of - 51.8 dB at 6.6 GHz with a thickness of 3 mm. This work not only provides a good design and fabricating concept for the laminated metal and functional nanoparticles@C nanocomposites with good EMW absorption, but also offers an important guideline to fabricate various two-dimensional nanocomposites derived from the MXene precursors.

SUBMITTER: Deng B

PROVIDER: S-EPMC7770802 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Similar Datasets

Project description:BackgroundNeuroblastoma is the most common extracranial solid malignancy in childhood which, despite the current progress in radiotherapy and chemotherapy protocols, still has a high mortality rate in high risk tumors. Nanomedicine offers exciting and unexploited opportunities to overcome the shortcomings of conventional medicine. The photocatalytic properties of Fe3O4 core-TiO2 shell nanocomposites and their potential for cell specific targeting suggest that nanoconstructs produced using Fe3O4 core-TiO2 shell nanocomposites could be used to enhance radiation effects in neuroblastoma. In this study, we evaluated bare, metaiodobenzylguanidine (MIBG) and 3,4-Dihydroxyphenylacetic acid (DOPAC) coated Fe3O4@TiO2 as potential radiosensitizers for neuroblastoma in vitro.ResultsThe uptake of bare and MIBG coated nanocomposites modestly sensitized neuroblastoma cells to ionizing radiation. Conversely, cells exposed to DOPAC coated nanocomposites exhibited a five-fold enhanced sensitivity to radiation, increased numbers of radiation induced DNA double-strand breaks, and apoptotic cell death. The addition of a peptide mimic of the epidermal growth factor (EGF) to nanoconjugates coated with MIBG altered their intracellular distribution. Cryo X-ray fluorescence microscopy tomography of frozen hydrated cells treated with these nanoconjugates revealed cytoplasmic as well as nuclear distribution of the nanoconstructs.ConclusionsThe intracellular distribution pattern of different nanoconjugates used in this study was different for different nanoconjugate surface molecules. Cells exposed to DOPAC covered nanoconjugates showed the smallest nanoconjugate uptake, with the most prominent pattern of large intracellular aggregates. Interestingly, cells treated with this nanoconjugate also showed the most pronounced radiosensitization effect in combination with the external beam x-ray irradiation. Further studies are necessary to evaluate mechanistic basis for this increased radiosensitization effect. Preliminary studies with the nanoparticles carrying an EGF mimicking peptide showed that this approach to targeting could perhaps be combined with a different approach to radiosensitization - use of nanoconjugates in combination with the radioactive iodine. Much additional work will be necessary in order to evaluate possible benefits of targeted nanoconjugates carrying radionuclides.Graphic abstractSupplementary informationThe online version contains supplementary material available at 10.1186/s12645-021-00081-z.

Dataset Information

Sandwich-Like Fe&TiO2@C Nanocomposites Derived from MXene/Fe-MOFs Hybrids for Electromagnetic Absorption.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Sandwich-Like Fe&TiO₂@C Nanocomposites Derived from MXene/Fe-MOFs Hybrids for Electromagnetic Absorption.