Ontology highlight
ABSTRACT:
SUBMITTER: Wolf K
PROVIDER: S-EPMC7770954 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Wolf Kyle K Hether Tyler T Gilchuk Pavlo P Kumar Amrendra A Rajeh Ahmad A Schiebout Courtney C Maybruck Julie J Buller R Mark RM Ahn Tae-Hyuk TH Joyce Sebastian S DiPaolo Richard J RJ
Cell reports 20181101 9
Tracking antigen-specific T cell responses over time within individuals is difficult because of lack of knowledge of antigen-specific TCR sequences, limitations in sample size, and assay sensitivities. We hypothesized that analyses of high-throughput sequencing of TCR clonotypes could provide functional readouts of individuals' immunological histories. Using high-throughput TCR sequencing, we develop a database of TCRβ sequences from large cohorts of mice before (naive) and after smallpox vaccin ...[more]