Dataset Information
The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men.
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ABSTRACT: Aim
To compare the effects of cold exposure and the ?3-adrenergic receptor agonist mirabegron on plasma lipids, energy expenditure and brown adipose tissue (BAT) activity in South Asians versus Europids.Materials and methods
Ten lean Dutch South Asian (aged 18-30?years; body mass index [BMI] 18-25 kg/m2 ) and 10 age- and BMI-matched Europid men participated in a randomized, double-blinded, cross-over study consisting of three interventions: short-term (~?2?hours) cold exposure, mirabegron (200?mg one dose p.o.) and placebo. Before and after each intervention, we performed lipidomic analysis in serum, assessed resting energy expenditure (REE) and skin temperature, and measured BAT fat fraction by magnetic resonance imaging.Results
In both ethnicities, cold exposure increased the levels of several serum lipid species, whereas mirabegron only increased free fatty acids. Cold exposure increased lipid oxidation in both ethnicities, while mirabegron increased lipid oxidation in Europids only. Cold exposure and mirabegron enhanced supraclavicular skin temperature in both ethnicities. Cold exposure decreased BAT fat fraction in both ethnicities. After the combination of data from both ethnicities, mirabegron decreased BAT fat fraction compared with placebo.Conclusions
In South Asians and Europids, cold exposure and mirabegron induced beneficial metabolic effects. When combining both ethnicities, cold exposure and mirabegron increased REE and lipid oxidation, coinciding with a higher supraclavicular skin temperature and lower BAT fat fraction.
SUBMITTER: Nahon KJ
PROVIDER: S-EPMC7771034 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men.
Diabetes, obesity & metabolism 20200729 11
<h4>Aim</h4>To compare the effects of cold exposure and the β3-adrenergic receptor agonist mirabegron on plasma lipids, energy expenditure and brown adipose tissue (BAT) activity in South Asians versus Europids.<h4>Materials and methods</h4>Ten lean Dutch South Asian (aged 18-30 years; body mass index [BMI] 18-25 kg/m<sup>2</sup> ) and 10 age- and BMI-matched Europid men participated in a randomized, double-blinded, cross-over study consisting of three interventions: short-term (~ 2 hours) cold ...[more]
