Ontology highlight
ABSTRACT:
SUBMITTER: Yin X
PROVIDER: S-EPMC7771208 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Yin Xiaozhe X Zeng Wenfeng W Wu Bowen B Wang Luoyang L Wang Zihao Z Tian Hongjian H Wang Luyao L Jiang Yunhan Y Clay Ryan R Wei Xiuli X Qin Yan Y Zhang Fayun F Zhang Chunling C Jin Lingtao L Liang Wei W
Cell reports 20201001 3
Dendritic cells (DCs) orchestrate the initiation, programming, and regulation of anti-tumor immune responses. Emerging evidence indicates that the tumor microenvironment (TME) induces immune dysfunctional tumor-infiltrating DCs (TIDCs), characterized with both increased intracellular lipid content and mitochondrial respiration. The underlying mechanism, however, remains largely unclear. Here, we report that fatty acid-carrying tumor-derived exosomes (TDEs) induce immune dysfunctional DCs to prom ...[more]