Ontology highlight
ABSTRACT:
SUBMITTER: Roska J
PROVIDER: S-EPMC7771712 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Roška Jan J Wachsmannová Lenka L Hurbanová Lenka L Šestáková Zuzana Z Mueller Thomas T Jurkovičová Dana D Chovanec Miroslav M
Oncotarget 20201222 51
Testicular germ cell tumors (TGCTs) represent a well curable malignity due to their exceptional response to cisplatin (CDDP). Despite remarkable treatment results, approximately 5% of TGCT patients develop CDDP resistance and die. Exceptional curability makes TGCTs a highly valuable model system for studying the molecular mechanisms of CDDP sensitivity. Our study was aimed at revealing difference in gene expression between the CDDP-resistant and -sensitive TGCT cell lines, and hence at identifyi ...[more]