Ontology highlight
ABSTRACT:
SUBMITTER: Ding L
PROVIDER: S-EPMC7772781 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Ding Li L Paszkowski-Rogacz Maciej M Mircetic Jovan J Chakraborty Debojyoti D Buchholz Frank F
Life science alliance 20201229 3
The RNA polymerase II (RNAPII) associated factor 1 complex (Paf1C) plays critical roles in modulating the release of paused RNAPII into productive elongation. However, regulation of Paf1C-mediated promoter-proximal pausing is complex and context dependent. In fact, in cancer cell lines, opposing models of Paf1Cs' role in RNAPII pause-release control have been proposed. Here, we show that the Paf1C positively regulates enhancer activity in mouse embryonic stem cells. In particular, our analyses r ...[more]