Dataset Information

Standardised computed tomographic assessment of left atrial morphology and tissue thickness in humans.

ABSTRACT:

Aims

Left atrial (LA) remodelling is a common feature of many cardiovascular pathologies and is a sensitive marker of adverse cardiovascular outcomes. The aim of this study was to establish normal ranges for LA parameters derived from coronary computed tomographic angiography (CCTA) imaging using a standardised image processing pipeline to establish normal ranges in a previously described cohort.

Methods

CCTA imaging from 193 subjects recruited to the Budapest GLOBAL twin study was analysed. Indexed LA cavity volume (LACV_i), LA surface area (LASA_i), wall thickness and LA tissue volume (LATV_i) were calculated. Wall thickness maps were combined into an atlas. Indexed LA parameters were compared with clinical variables to identify early markers of pathological remodelling.

Results

LACV_i is similar between sexes (31 ml/m² v 30 ml/m²) and increased in hypertension (33 ml/m² v 29 ml/m², p = 0.009). LASA_i is greater in females than males (47.8 ml/m² v 45.8 ml/m² male, p = 0.031). Median LAWT was 1.45 mm. LAWT was lowest at the inferior portion of the posterior LA wall (1.14 mm) and greatest in the septum (median = 2.0 mm) (p < 0.001). Conditions known to predispose to the development of AF were not associated with differences in tissue thickness.

Conclusions

The reported LACV_i, LASA_i, LATV_i and tissue thickness derived from CCTA may serve as reference values for this age group and clinical characteristics for future studies. Increased LASA_i in females in the absence of differences in LACV_i or LATV_i may indicate differential LA shape changes between the sexes. AF predisposing conditions, other than sex, were not associated with detectable changes in LAWT.Clinical trial registration:http://www.ClinicalTrials.gov/NCT01738828.

SUBMITTER: Whitaker J

PROVIDER: S-EPMC7772783 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Standardised computed tomographic assessment of left atrial morphology and tissue thickness in humans.

Whitaker John J Karády Júlia J Karim Rashed R Tobon-Gomez Catalina C Fastl Thomas T Razeghi Orod O O'Neill Louisa L Decroocq Marie M Williams Steven S Corrado Cesare C Mukherjee Rahul K RK Sim Iain I O'Hare Daniel D Kotadia Irum I Kolossváry Márton M Merkely Bela B Littvay Levente L Tarnoki Adam D AD Tarnoki David L DL Voros Szilard S Razavi Reza R O'Neill Mark M Rajani Ronak R Maurovich Horvat Pál P Niederer Steven S

International journal of cardiology. Heart & vasculature 20201224

<h4>Aims</h4>Left atrial (LA) remodelling is a common feature of many cardiovascular pathologies and is a sensitive marker of adverse cardiovascular outcomes. The aim of this study was to establish normal ranges for LA parameters derived from coronary computed tomographic angiography (CCTA) imaging using a standardised image processing pipeline to establish normal ranges in a previously described cohort.<h4>Methods</h4>CCTA imaging from 193 subjects recruited to the Budapest GLOBAL twin study wa ...[more]

PMID: 33392384

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Dataset Information

Standardised computed tomographic assessment of left atrial morphology and tissue thickness in humans.

Aims

Methods

Results

Conclusions

Publications

Standardised computed tomographic assessment of left atrial morphology and tissue thickness in humans.

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