Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase.
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ABSTRACT:
SUBMITTER: Van Ly D
PROVIDER: S-EPMC7772867 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase.
Van Ly David D Wang Duo D Conway Robert Max RM Giblin Michael M Liang Sharron S Lukeis Robyn R Lim Li-Anne LA Hesson Luke L Cherepanoff Svetlana S
Ocular oncology and pathology 20201009 6
Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the clinical, histological, immunohistochemical, and molecular findings in a ciliochoroidal melanoma with lipid production and expression of the enzyme HMG-CoA reductase. This case highlights an unusual UM tumour phenotype with a high-risk molecular metastatic profile and discusses tumour lipogenesis and activation of the mevalonate pathway a ...[more]
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