Ontology highlight
ABSTRACT:
SUBMITTER: Chen HL
PROVIDER: S-EPMC7773376 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Chen Hung-Lin HL Lo Chia-Hui CH Huang Chi-Chun CC Lu Meng-Ping MP Hu Po-Yuan PY Chen Chang-Shan CS Chueh Di-Yen DY Chen Peilin P Lin Teng-Nan TN Lo Yuan-Hsin YH Hsiao Yu-Ping YP Hsu Daniel K DK Liu Fu-Tong FT
The Journal of clinical investigation 20210101 1
Psoriasis is a chronic inflammatory skin disease characterized by inflammatory cell infiltration, as well as hyperproliferation of keratinocytes in skin lesions, and is considered a metabolic syndrome. We found that the expression of galectin-7 is reduced in skin lesions of patients with psoriasis. IL-17A and TNF-α, 2 cytokines intimately involved in the development of psoriatic lesions, suppressed galectin-7 expression in human primary keratinocytes (HEKn cells) and the immortalized human kerat ...[more]