Ontology highlight
ABSTRACT:
SUBMITTER: Uezumi A
PROVIDER: S-EPMC7773381 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Uezumi Akiyoshi A Ikemoto-Uezumi Madoka M Zhou Heying H Kurosawa Tamaki T Yoshimoto Yuki Y Nakatani Masashi M Hitachi Keisuke K Yamaguchi Hisateru H Wakatsuki Shuji S Araki Toshiyuki T Morita Mitsuhiro M Yamada Harumoto H Toyoda Masashi M Kanazawa Nobuo N Nakazawa Tatsu T Hino Jun J Fukada So-Ichiro SI Tsuchida Kunihiro K
The Journal of clinical investigation 20210101 1
Age-related sarcopenia constitutes an important health problem associated with adverse outcomes. Sarcopenia is closely associated with fat infiltration in muscle, which is attributable to interstitial mesenchymal progenitors. Mesenchymal progenitors are nonmyogenic in nature but are required for homeostatic muscle maintenance. However, the underlying mechanism of mesenchymal progenitor-dependent muscle maintenance is not clear, nor is the precise role of mesenchymal progenitors in sarcopenia. He ...[more]