NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression.
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ABSTRACT:
SUBMITTER: Sanchez-de-Diego C
PROVIDER: S-EPMC7773566 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
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NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression.
Sánchez-de-Diego Cristina C Pedrazza Leonardo L Pimenta-Lopes Carolina C Martinez-Martinez Arturo A Dahdah Norma N Valer José Antonio JA Garcia-Roves Pablo P Rosa Jose Luis JL Ventura Francesc F
Redox biology 20201224
Osteocytes, the most abundant bone cell type, are derived from osteoblasts through a process in which they are embedded in an osteoid. We previously showed that nutrient restriction promotes the osteocyte transcriptional program and is associated with increased mitochondrial biogenesis. Here, we show that increased mitochondrial biogenesis increase reactive oxygen species (ROS) levels and consequently, NRF2 activity during osteocytogenesis. NRF2 activity promotes osteocyte-specific expression of ...[more]
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